Seven years after scientists successfully managed to adapt a gene editing system used by bacteria into one that can be easily used in labs to edit human genes, we take a look at some of the emerging applications and ethical issues of CRISPR-Cas9. We talk to the head of the European Group on Ethics in Science and New Technologies about whether the simplicity and low cost of CRISPR means that there is potential for misuse and what should be done about this. We find out how scientists have used CRISPR to create cows lacking two sugars that trigger the human immune system, leading to hopes of longer-lasting heart valves for transplant patients and healthier red meat. And we speak to researchers who are using CRISPR to improve other gene editing technologies.
We need an active public debate on the ethics of gene editing technology to realise its potential and prevent it being used in nefarious ways, for example by the military and amateur scientists, and to take cultural differences into account, according to Professor Christiane Woopen, executive director of the Centre for Ethics, Rights, Economics and Social Sciences of Health (CERES) at Germany’s University of Cologne.
Thanks to the ‘cut and paste’ gene editing technique CRISPR, scientists are homing in on a cure for sickle cell disease - a genetic blood disorder - while other research is looking at how to expand the potential of CRISPR-based treatments.
In November, Horizon takes a deep dive into the captivating, diverse world of clouds to understand what they mean for climate change. We speak to atmospheric physicist Prof. Pier Siebesma about why clouds are still one of the biggest sources of uncertainty when it comes to climate change and how new field studies are helping to reduce some of the unknowns. We speak to a researcher about flying through tropical clouds to collect particles at high altitudes to paint a full picture of the role of clouds and aerosols in our planet’s climate. And we also delve into research investigating how global warming is changing clouds and why this could bring about extreme weather and rain, and we look at how aerosols – crucial for cloud formation - are changing due to anthropogenic pollution.
In October, Horizon discovers a futuristic world of transparent e-books, plastic solar cells and electronic skin with a look at some of the applications of organic electronics. We speak to organic chemist Prof. Andreas Hirsch about how using carbon rather than silicon in electronics can make them flexible, lightweight and biocompatible and could lead to a new generation of human-looking robots and ‘chemical’ computing. We take a look at work to create electronic skin – self-healing, stretchable material that can mimic some of the functions of human skin – and its potential uses. We discover how thin, flexible, plastic solar cells could turn surfaces such as cars and fabric into sources of renewable energy, and we uncover some novel approaches to charging wearable electronics.
Particles swirling around our atmosphere add to climate change, yet much about how they interact with sunlight and influence the seeding of clouds remains puzzling. Studies are lifting the lid on how these tiny particles influence something as big as climate by analysing them from jet aircraft, satellites and ground measurements.
Live vaccines can give health effects beyond just protecting us from a specific disease and may even help us combat other infections such as Covid-19, according to Christine Stabell Benn, a professor in global health at the University of Southern Denmark.
Different particle types affect our climate in various ways.
Different people respond to medication in different ways – and the results can be fatal.
Dr Kate Rychert studies ocean plate structures.