Seven years after scientists successfully managed to adapt a gene editing system used by bacteria into one that can be easily used in labs to edit human genes, we take a look at some of the emerging applications and ethical issues of CRISPR-Cas9. We talk to the head of the European Group on Ethics in Science and New Technologies about whether the simplicity and low cost of CRISPR means that there is potential for misuse and what should be done about this. We find out how scientists have used CRISPR to create cows lacking two sugars that trigger the human immune system, leading to hopes of longer-lasting heart valves for transplant patients and healthier red meat. And we speak to researchers who are using CRISPR to improve other gene editing technologies.
We need an active public debate on the ethics of gene editing technology to realise its potential and prevent it being used in nefarious ways, for example by the military and amateur scientists, and to take cultural differences into account, according to Professor Christiane Woopen, executive director of the Centre for Ethics, Rights, Economics and Social Sciences of Health (CERES) at Germany’s University of Cologne.
Thanks to the ‘cut and paste’ gene editing technique CRISPR, scientists are homing in on a cure for sickle cell disease - a genetic blood disorder - while other research is looking at how to expand the potential of CRISPR-based treatments.
In June, against a backdrop of the coronavirus pandemic, a climate emergency and an uncertain future, Horizon takes a look at anxiety. Are we becoming more anxious? What do we really know about the condition and who suffers from it? And how can we best treat it? We speak to anxiety disorder expert Professor David Baldwin about when anxiety turns from a normal response into a long-term problem and what we know – and don’t – about why this happens. We take a look at one particularly vulnerable group – teenagers – to understand how anxiety affects them and how they can best be treated. We explore the link between anxiety and our awareness of bodily sensations to understand, for example, why breathing can calm the mind, and we also talk to the researchers who believe the key to improving anxiety therapies is to look at how different people respond when under threat.
By 2050, the world's population will be an estimated 9.7bn people, up from today’s 7.7bn. To feed this growing population whilst also protecting the climate and biodiversity, our food system needs to change dramatically. In May, we look at what sort of future food system we want and how to get there. We speak to sustainability expert Prof. Peter Jackson about how lockdowns have exposed our reliance on fragile supply chains, and what needs to happen to shape a more sustainable food system. We look at the smart farming solutions that are being explored to support food producers, and urban experiments from tackling food waste to strengthening organic, local production to see how these efforts can be scaled up to make a big difference. And we investigate insects – a protein-rich food and feed source – and the efforts behind mainstreaming what is still a niche science.
In our continuing search for other life in the universe, one place has always looked promising – Mars. It is a rocky planet like Earth, orbiting the same star, and at a distance where water could have been present on the planet.
Moving more goods by water could reduce pressure on roads and cut emissions, yet Europe’s shipping industry is held back by labour shortages. Automated shipping – which would work in a similar way to self-driving cars – could help expand capacity but safety and regulatory hurdles remain.
The red planet may be our best bet for finding out whether we’re alone in the universe.
Reducing crew numbers onboard ships could overcome labour shortages and increase shipping levels.
Metagenomics can help us spot emerging diseases such as coronavirus, says virologist Marion Koopmans.