All over the world, bacteria are becoming resistant to antibiotics, making infections more difficult – and in some cases impossible – to treat. It’s one of today’s biggest public health challenges and this month Horizon examines how scientists are working to overcome this growing issue. We speak to microbiologist Dr Nassos Typas about how we got here, what causes resistance to antibiotics and the different approaches being explored to combat resistance. We look at renewed efforts to find new antibiotics and ask whether it’s possible to reverse antibiotic resistance. And with dairy being a huge food source and also an antibiotic-intensive industry, we speak to scientists who are developing alternative therapies for treating cows for mastitis as a way of curbing antibiotics from coursing through our food chain.
If you think that the key to beating antibiotic resistance is only for doctors to prescribe less and scientists to find new drug candidates, you are probably wrong. The fundamental solutions may lie far from medicine – in managing our rivers and soils.
New weapons are needed to fight drug-resistant bacteria, one of the biggest threats to global health. By working on new antibiotics or finding ways to revive existing ones in our medical arsenal, scientists aim to avoid a return to a world where even everyday infections may mean death.
As the global antibiotic resistance crisis grows, chemical-based aerosol sprays and electrical signals to wake up the immune system are being developed to treat cow infections. These non-antibiotic therapies for livestock could also help to limit the spread of antibiotic resistance through the human food chain.
Finding ways to enlist the bacteria living in our bodies to defend against infections while better understanding their role in promoting antibiotic resistance are key to fighting this growing problem, says Dr Nassos Typas, a microbiologist at the European Molecular Biology Laboratory in Heidelberg, Germany.
The world looks very different from this time last year. The coronavirus pandemic has highlighted the centrality of science, research and innovation, accelerated some changes already in the works, but also exposed our weaknesses. In September, Horizon looks at how the pandemic is reshaping Europe in areas including health research, work, tech, transport and food – and how research can contribute to Europe’s recovery over the coming years. We will also be covering the European Research & Innovation Days at the end of the month, which will bring together scientists, policymakers, entrepreneurs and citizens to debate how research and innovation can ensure that the transition to a post-coronavirus society is sustainable, inclusive and resilient.
In August, Horizon looks at one of the features that makes Earth unique and habitable: plate tectonics. We explore what we know – and still don’t know – about how the shifting plates beneath our feet shape our planet. We speak to researcher Dr Kate Rychert, who wants to understand what makes a plate plate-like, and delve into one of the outstanding mysteries in the subject – how and why plate tectonics began. We find out about the link between mountain formation, erosion and climate change, and we look at what moonquakes and marsquakes can reveal about tectonic activity elsewhere.
The ability of certain fish to heal damage to their hearts could lead to new treatments for patients who have suffered heart attacks and may also help to unravel how the lifestyle of our parents and grandparents can affect our own heart health.
A strange species of cavefish is helping to reveal why heart attacks cause permanent damage.
‘Industrial symbiosis’ is encouraging industry byproducts to be used for new purposes.
Dr Kate Rychert studies ocean plate structures.